A Solvable Model for Polymorphic Dynamics of Biofilaments

We investigate an analytically tractable toy model for thermally induced polymorphic dynamics of cooperatively rearranging biofilaments - like microtubules. The proposed 4 -block model, which can be seen as a coarse-grained approximation of the full polymorphic tube model, permits a complete analytical treatment of all thermodynamic properties including correlation functions and angular fourier mode distributions. Due to its mathematical tractability the model straightforwardly leads to some physical insights in recently discussed phenomena like the "length dependent persistence length". We show that a polymorphic filament can disguise itself as a classical worm like chain on small and on large scales and yet display distinct anomalous tell-tale features indicating an inner switching dynamics on intermediate length scales

Evolution of the Great Tehuelche Paleolake in the Torres del Paine National Park of Chilean Patagonia during the Last Glacial Maximum and Holocene

Indexación: Web of Science; ScieloRESUMEN. Una serie de morrenas glaciares se distribuyen desde el margen oriental de la cuenca de drenaje Torres del Paine a cerca del actual margen de los Campos de Hielo Patagónico, junto con una serie de terrazas lacustres regional continuos relacionados con las fluctuaciones glaciales. La geomorfología, apoyada por la evidencia de sedimentos del lago, indica la existencia de un único paleolago proglacial en esta zona, aquí denominado el Gran Tehuelche paleolago. Este concepto ayuda a aclarar la cronología de eventos glaciales y conduce a una mejor comprensión de la evolución del sistema hidrológico de la zona de Torres del Paine. Avances glaciales referidos anteriormente como ocurrieron A, B y C durante el Último Máximo Glacial y alimentados con la Gran Tehuelche paleolago con agua de deshielo, que le permite alcanzar su máxima extensión. El descubrimiento de trombolitos en Laguna Amarga sugiere que el drenaje de la paleolago hacia el fiordo de Última Esperanza tuvo lugar en 7113 Cal. años AP, después de la fusión de una barrera de hielo que existía durante el avance glacial antes. Esto dio lugar al desarrollo de un sistema hidrológico fluvio-lacustre complejo que persiste hasta nuestros días. Palabras clave: Patagonia, último máximo glacial, Younger Dryas, trombolitos. RESUMEN. Un grupo de morrenas glaciales estan Distribuidas desde el margen Este de la cuenca de drenaje de Torres del Paine Hacia el margen real de los Campos de Hielo Patagónicos. Las morrenas se observan en conjunto con las Naciones Unidas Grupo de terrazas Lacustres Regionales, las Cuales estan vinculadas y una las fluctuaciones glaciales. La geomorfología y Evidencias de sedimentos Lacustres indicano la existence De unico ONU lago proglacial, referido En Este Estudio de Como Gran Paleolago Tehuelche. Este Concepto ayuda a clarificar la cronología de los eventos glaciales y permite Una mejor Comprensión de la Evolución del Sistema hidrológico del sector de Torres del Paine. Los eventos glaciales, previamente Referidos Como Avance A, B y C, ocurrieron Durante el Último Máximo Glacial y alimentaron con Aguas de fusión al Gran Paleolago Tehuelche, permitiéndole Alcanzar su alcalde extensión. El Descubrimiento de trombolitos en Laguna Amarga sugiere Que El desagüe del paleolago Ocurrió Hace 7.113 Cal. Por años AP el Seno de Última Esperanza, producto de la fusión De Una barrera glaciar existente Durante los Avances glaciales Anteriores. LUEGO del drenaje sí Desarrollo en Un complejo Sistema hidrológico Que Persiste Hasta el presente. Palabras clave: Patagonia, Último Máximo Glacial, Dryas Temprano, Trombolitos.http://ref.scielo.org/wgc2q

LoCuSS: Hydrostatic Mass Measurements of the High-LXL_X Cluster Sample -- Cross-calibration of Chandra and XMM-Newton

We present a consistent analysis of Chandra and XMM-Newton observations of an approximately mass-selected sample of 50 galaxy clusters at $0.15<z<0.3$ -- the "LoCuSS High-$L_X$ Sample". We apply the same analysis methods to data from both satellites, including newly developed analytic background models that predict the spatial variation of the Chandra and XMM-Newton backgrounds to $<2\%$ and $<5\%$ precision respectively. To verify the cross-calibration of Chandra and XMM-Newton-based cluster mass measurements, we derive the mass profiles of the 21 clusters that have been observed with both satellites, extracting surface brightness and temperature profiles from identical regions of the respective datasets. We obtain consistent results for the gas and total hydrostatic cluster masses: the average ratio of Chandra- to XMM-Newton-based measurements of $M_{\rm gas}$ and $M_X$ at $r_{500}$ are $0.99\pm0.02$ and $1.02\pm0.05$, respectively with an intrinsic scatter of $\sim3\%$ for gas masses and $\sim8\%$ for hydrostatic masses. Comparison of our hydrostatic mass measurements at $r_{500}$ with the latest LoCuSS weak-lensing results indicate that the data are consistent with non-thermal pressure support at this radius of $\sim7\%$. We also investigate the scaling relation between our hydrostatic cluster masses and published integrated Compton parameter $Y_{sph}$ measurements from the Sunyaev-Zel'dovich Array. We measure a scatter in mass at fixed $Y_{sph}$ of $\sim16\%$ at $\Delta=500$, which is consistent with theoretical predictions of $\sim10-15\%$ scatter.Comment: 21 pages, 11 figure

Limited sampling strategies to estimate glomerular filtration rate in cats with low, normal and high glomerular filtration rates

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Dirac Particles in a Gravitational Field

The semiclassical approximation for the Hamiltonian of Dirac particles interacting with an arbitrary gravitational field is investigated. The time dependence of the metrics leads to new contributions to the in-band energy operator in comparison to previous works on the static case. In particular we find a new coupling term between the linear momentum and the spin, as well as couplings which contribute to the breaking of the particle - antiparticle symmetry

Developing the Technique of Measurements of Magnetic Field in the CMS Steel Yoke Elements With Flux-Loops and Hall Probes

Compact muon solenoid (CMS) is a general-purpose detector designed to run at the highest luminosity at the CERN large hadron collider (LHC). Its distinctive features include a 4 T superconducting solenoid with 6 m diameter by 12.5 m long free bore, enclosed inside a 10000-ton return yoke made of construction steel. Accurate characterization of the magnetic field everywhere in theCMSdetector, including the large ferromagnetic parts of the yoke, is required. To measure the field in and around ferromagnetic parts, a set of flux-loops and Hall probe sensors will be installed on several of the steel pieces. Fast discharges of the solenoid during system commissioning tests will be used to induce voltages in the flux-loops that can be integrated to measure the flux in the steel at full excitation of the solenoid. The Hall sensors will give supplementary information on the axial magnetic field and permit estimation of the remanent field in the steel after the fast discharge. An experimental R&D program has been undertaken, using a test flux-loop, two Hall sensors, and sample disks made from the same construction steel used for the CMS magnet yoke. A sample disc, assembled with the test flux-loop and the Hall sensors, was inserted between the pole tips of a dipole electromagnet equipped with a computer-controlled power supply to measure the excitation of the steel from full saturation to zero field. The results of the measurements are presented and discussed.Comment: 6 pages, 8 figures, 6 reference

Adding Salt to an Aqueous Solution of t-Butanol: Is Hydrophobic Association Enhanced or Reduced?

Recent neutron scattering experiments on aqueous salt solutions of amphiphilic t-butanol by Bowron and Finney [Phys. Rev. Lett. {\bf 89}, 215508 (2002); J. Chem. Phys. {\bf 118}, 8357 (2003)] suggest the formation of t-butanol pairs, bridged by a chloride ion via ${O}-{H}...{Cl}^-$ hydrogen-bonds, and leading to a reduced number of intermolecular hydrophobic butanol-butanol contacts. Here we present a joint experimental/theoretical study on the same system, using a combination of molecular dynamics simulations and nuclear magnetic relaxation measurements. Both theory and experiment clearly support the more intuitive scenario of an enhanced number of hydrophobic contacts in the presence of the salt, as it would be expected for purely hydrophobic solutes [J. Phys. Chem. B {\bf 107}, 612 (2003)]. Although our conclusions arrive at a structurally completely distinct scenario, the molecular dynamics simulation results are within the experimental errorbars of the Bowron and Finney work.Comment: 15 pages twocolumn revtex, 11 figure

Helices at Interfaces

Helically coiled filaments are a frequent motif in nature. In situations commonly encountered in experiments coiled helices are squeezed flat onto two dimensional surfaces. Under such 2-D confinement helices form "squeelices" - peculiar squeezed conformations often resembling looped waves, spirals or circles. Using theory and Monte-Carlo simulations we illuminate here the mechanics and the unusual statistical mechanics of confined helices and show that their fluctuations can be understood in terms of moving and interacting discrete particle-like entities - the "twist-kinks". We show that confined filaments can thermally switch between discrete topological twist quantized states, with some of the states exhibiting dramatically enhanced circularization probability while others displaying surprising hyperflexibility